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The Infiniium real time scope with InfiniiSim de-embedding software allows you measure signals wherever you want, not just where you can place a probe easily. But to do this, you need the s-parameters between the probe and the point of interest. The s-parameters could come from measurement, but this reopens the problem of getting a probe on the point of interest. The first part of this paper shows how you can use 3D geometry, material properties, and electromagnetic simulation to create the de-embedding information even for points of interest that are inaccessible. In the second part of the paper we'll show how to explore the design space without the expensive and time consuming "cut and try" method of building and measuring many different prototypes. We'll show how to use measured data from hardware that has been build and use simulation with EDA tools to quickly and cheaply determine the characteristics of candidates that haven't been built yet. For more information: http://www.agilent.com/find/eesof-si-solutions For a free evaluation copy of ADS: http://www.agilent.com/find/eesof-ads-latest-downloads